Markers of Bone Turnover and 25-Hydroxy Vitamin D in Women with Type 2 Diabetes and Newly Diagnosed Osteoporosis

Raluca Nan, Adrian Cursaru, Daniel Grigorie, Alina Şucaliuc, Ramona M. Drăguţ, Emilia Rusu, Mădălina D. Muşat, Gabriela Radulian
2016 Romanian Journal of Diabetes Nutrition and Metabolic Diseases  
and Aims: The aim of the present study was to evaluate the characteristics of bone turnover markers and 25-hydroxy vitamin D levels in women with type 2 diabetes and recently diagnosed postmenopausal osteoporosis. Material and Methods: We performed a retrospective study that included 80 women with newly diagnosed postmenopausal osteoporosis: 40 women with type 2 diabetes (diabetic group) and 40 women without diabetes (non-diabetic group). For data collection we used the patients database
more » ... nts database Results: Women with type 2 diabetes had significantly reduced levels of osteocalcin and crosslaps than non-diabetic women. In the diabetic group, alkaline phosphatase and 25hydroxy vitamin D were lower than in non-diabetic women but without statistical significance. There was not statistically significant difference of bone mineral density (BMD) between diabetic and non-diabetic groups. Magnesium was significantly lower in diabetic women compared with non-diabetic women. Conclusions: Our results demonstrated a low bone turnover in type 2 diabetic women and it was shown an insufficiency of 25-hydroxy vitamin D in both studied groups. These findings should be taken into account when screening these patients for diabetes complications. key words: type 2 diabetes, osteocalcin, crosslaps, bone mineral density.
doi:10.1515/rjdnmd-2016-0009 fatcat:rzisi3srczarhmkobcptd3x5we