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Network medicine for disease module identification and drug repurposing with the NeDRex platform
2021
Nature Communications
AbstractTraditional drug discovery faces a severe efficacy crisis. Repurposing of registered drugs provides an alternative with lower costs and faster drug development timelines. However, the data necessary for the identification of disease modules, i.e. pathways and sub-networks describing the mechanisms of complex diseases which contain potential drug targets, are scattered across independent databases. Moreover, existing studies are limited to predictions for specific diseases or
doi:10.1038/s41467-021-27138-2
pmid:34824199
pmcid:PMC8617287
fatcat:czmxg3x3cbczvaqdvixh5ptt4i