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Vincristine-induced peripheral neuropathy (VIPN) is a prevalent and painful complication in cancer patients that lacks effective treatments. In this issue of JEM, Starobova et al. (2021. J. Exp. Med.https://doi.org/10.1084/jem.20201452) report that VIPN is driven by innate immune system activation, a discovery that unlocks immunotherapies as potential treatments.doi:10.1084/jem.20210286 pmid:33751022 pmcid:PMC7992412 fatcat:2kbx6uetvfeh5bnnbvfbelluo4