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Structural and functional alterations in the retrosplenial cortex following neuropathic pain
Human and animal imaging studies demonstrated that chronic pain profoundly alters the structure and the functionality of several brain regions. In this article, we conducted a longitudinal and multimodal study to assess how chronic pain affects the brain. Using the spared nerve injury model which promotes both long-lasting mechanical and thermal allodynia/hyperalgesia but also pain-associated comorbidities, we showed that neuropathic pain deeply modified the intrinsic organization of the braindoi:10.1097/j.pain.0000000000001610 pmid:31145220 fatcat:6g3hlk4zrrawhpubpbvsnhxywq