Association of Glycosylated Haemoglobin Level with the Severity of Coronary Artery Disease in NSTEMI Diabetic Patients

Mahmod Mohammad Salim, Malik Fazila Tun Nesa, Rahman Mohammad Arif, Hossain Mohammad Delwar, Mandal Md Raihan Masum
2015 Cardiovascular Journal  
<p><strong>Background: </strong>Relation between diabetes mellitus and ischemic heart disease is well established. But the effect of HbA<sub>1C</sub> on severity of coronary artery disease remains uncertain in non-ST elevation myocardial infarction and diabetic patient. Objective of our study was to know the relationship of HbA<sub>1C</sub> with the severity of coronary artery disease.</p><p><strong>Methods: </strong>In this cross sectional analytical study a total of 104 NSTEMI diabetic
more » ... s were enrolled by purposive sampling. They were divided into two groups according to the level of HbA<sub>1C</sub>, Group-I patients having HbA<sub>1C</sub>&lt;7% and Group-II patients having HbA<sub>1C</sub> &gt;7%. Vessel score and Gensini score was calculated from coronary angiogram and compared between groups.</p><p><strong>Results: </strong>Single vessel disease were significantly higher in group-I compared to Group-II( 38.5% vs 7.7% in Group-I vs Group-II,p&lt;0.05). Double vessel disease were higher in group-II compared to Group-I but the difference was statistically not significant (42.3% vs 48.1% in Group-I vs Group-II respectively (p&gt;0.05). Triple vessel disease were significantly higher in group-II compared to Group- I (19.2% vs 44.4% in Group-I vs Group-II,p&lt;0.05). Mean Vessel score was higher in Group-II compared to Group-I(1.73 ± 0.86 vs 2.50 ±0.70 in Group-I vs Group-II, p&lt;0.05). Mean Gensini score was higher in Group-II compared to Group-I (44.6 ± 38.4 vs 76.9 ± 44.6 in Group-I vs Group-II, p&lt;0.05). There were significant positive linear correlation between HbA1C and Vessels score and Gensini score (p&lt;0.05).</p><p><strong>Conclusion: </strong>This study may be concluded that the presence of HbA<sub>1C</sub> &gt;7% are associated with of severe coronary artery disease in NSTEMI with diabetes mellitus.</p><p>Cardiovasc. j. 2015; 8(1): 43-48</p>
doi:10.3329/cardio.v8i1.24767 fatcat:ssquni2orndrjibhvhgnnfjsoy