This study was carried on four groups of Wistar male rats (20 of each), to evaluate the protective effect of vitamin E and selenium on the structure and biochemical alterations of the liver, heart and aorta. Group I is control, Group II fed high fat and vitamin E and selenium deficient diet as control positive group. Group III (protective) given 100 mg and 0.1 mg/kg b.w/day for 6months, vitamin E and selenium respectively with high fat diet. Group IV were injected intra peritoneal Vitamin E and

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... selenium 1 g/100 g b.w for 6 months after feeding high fat diet for 6 months. At the end of experimental design, histological section from liver, heart and aorta and so serum changes in metabolites of heart and liver were examined. The tissues of the control posi-