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Pseudogene legumain promotes thyroid carcinoma progression via the microRNA‑495/autophagy pathway

Jie Sun, Yicheng Peng, Jianxia Liu, Hao Zhou, Liang Sun, Qin He, Enqiao Yu
2021 Oncology Letters  

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The pseudogene legumain (LGMN) has been reported to regulate cancer cell biology. However, the role of LGMN in thyroid carcinoma remains unknown. Herein, Cell Counting Kit 8 and Transwell assays were performed to evaluate cellular proliferation and invasion capacity, respectively. In addition, a tube formation assay was performed to assess HUVEC angiogenesis. The results showed that LGMN depletion attenuated cellular proliferation, invasion and tube formation ability, and that LGMN expression
more » ... s dysregulated in thyroid carcinoma tumors. Furthermore, patients with high LGMN expression levels exhibited a lower overall survival rate than those with low expression levels. LGMN and microRNA (miR)-495 modulated the expression levels of autophagy-related gene 3 (ATG3) and p62. Finally, ATG3 overexpression rescued the LGMN-regulated thyroid carcinoma phenotype. In conclusion, LGMN was found to promote thyroid carcinoma progression via the miR-495/autophagy axis, thus providing novel insights for understanding the pathogenesis of thyroid carcinoma.
doi:10.3892/ol.2021.12877 fatcat:rul2cmubb5f6lo2qaphurrqc74
Citation

Jie Sun, Yicheng Peng, Jianxia Liu, Hao Zhou, Liang Sun, Qin He, Enqiao Yu. "Pseudogene legumain promotes thyroid carcinoma progression via the microRNA‑495/autophagy pathway." Oncology Letters 22.2 (2021)