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Leukocyte integrin Mac-1 (CD11b/CD18, αMβ2, CR3) acts as a functional receptor for platelet factor 4
2018
Journal of Biological Chemistry
Edited by Peter Cresswell Platelet factor 4 (PF4) is one of the most abundant cationic proteins secreted from ␣-granules of activated platelets. Based on its structure, PF4 was assigned to the CXC family of chemokines and has been shown to have numerous effects on myeloid leukocytes. However, the receptor for PF4 remains unknown. Here, we demonstrate that PF4 induces leukocyte responses through the integrin Mac-1 (␣ M  2 , CD11b/CD18). Human neutrophils, monocytes, U937 monocytic and HEK293
doi:10.1074/jbc.ra117.000515
pmid:29540475
fatcat:dhyavwatgvgyrbvcm4uddp4jxy