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CNS Wound Healing Is Severely Depressed in Metallothionein I- and II-Deficient Mice
Journal of Neuroscience
To characterize the physiological role of metallothioneins I and II (MT-IϩII) in the brain, we have examined the chronological effects of a freeze injury to the cortex in normal and MT-IϩII null mice. In normal mice, microglia/macrophage activation and astrocytosis were observed in the areas surrounding the lesion site, peaking at ϳ1 and 3 d postlesion (dpl), respectively. At 20 dpl, the parenchyma had regenerated. Both brain macrophages and astrocytes surrounding the lesion increased thedoi:10.1523/jneurosci.19-07-02535.1999 pmid:10087067 fatcat:uxb6iq6fqzb7xbns6paaej7fwu