FEATnotator: A tool for integrated annotation of sequence features and variation, facilitating interpretation in genomics experiments

Ram Podicheti, Keithanne Mockaitis
2015 Methods  
As approaches are sought for more efficient and democratized uses of non-model and expanded model genomics references, ease of integration of genomic feature datasets is especially desirable in multidisciplinary research communities. Valuable genomic conclusions are often missed or slowed when researchers refer experimental results to a single reference sequence that lacks integrated pan-genomic and multi-experiment data in accessible formats. Association of genomic positional information, such
more » ... as results from an expansive variety of next-generation sequencing experiments, with annotated reference features such as genes or predicted protein binding sites, provides the context essential for conclusions and ongoing research. When the experimental system includes polymorphic genomic inputs, rapid calculation of gene structural and protein translational effects of sequence variation from the reference can be invaluable. Here we present FEATnotator, a lightweight, fast and easy to use open source software program that © 2015. This manuscript version is made available under the Elsevier user license
doi:10.1016/j.ymeth.2015.04.028 pmid:25934264 fatcat:5bdztvdijjaufpgbxwc5nj5xge