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Canonical DNA Repair Pathways Influence R-Loop-Driven Genome Instability
2017
Journal of Molecular Biology
DNA repair defects create cancer predisposition in humans by fostering a higher rate of mutations. While DNA repair is quite well characterized, recent studies have identified previously unrecognized relationships between DNA repair and R-loop-mediated genome instability. R-loops are three stranded nucleic acid structures in which RNA binds to genomic DNA to displace a loop of single-stranded DNA. Mutations in homologous recombination, nucleotide excision repair, crosslink repair and DNA damage
doi:10.1016/j.jmb.2016.07.014
pmid:27452366
pmcid:PMC5253333
fatcat:gnvlzlrzo5fzhghw4r6y4f6phi