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Prediction of a highly deleterious mutation E17K in AKT-1 gene: An in silico approach
2017
Biochemistry and Biophysics Reports
The AKT1 (v-akt murine thymoma viral oncogene homologue 1) kinase is a member of most frequently activated proliferation and survival signaling pathway in cancer. Recently, hyperactivation of AKT1, due to functional point mutation in the pleckstrin homology (PH) domain of AKT1 gene, has been found to be associated with human colorectal, breast and ovarian cancer. Thus, considering its crucial role in cellular signaling pathway, a functional analysis of missense mutations of AKT1 gene was
doi:10.1016/j.bbrep.2017.04.013
pmid:29114575
pmcid:PMC5637233
fatcat:m4tamsguj5bltkmnxtor3h4nh4