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Endothelins Stimulate Deoxyribonucleic Acid Synthesis and Cell Proliferation in Rat Adrenal Zona Glomerulosa, Acting through an Endothelin A Receptor Coupled with Protein Kinase C- and Tyrosine Kinase-Dependent Signaling Pathways
The effects of endothelins (ET) on the proliferative activity of the rat adrenal cortex have been investigated in vivo, using an in situ perfusion technique of the intact left gland. The chemicals were dissolved in the perfusion medium, and the perfusion continued for 120 min. ET-1 concentration dependently increased the mitotic index and [ 3 H]thymidine incorporation into DNA in the zona glomerulosa (ZG; 6-and 3-fold increases, respectively, at a 10 Ϫ8 M concentration), but not in the innerdoi:10.1210/endo.138.6.5191 pmid:9165019 fatcat:uf365i4jynhnzmvj3pyjisxsuy