Relationship of Forced Vital Capacity (FVC), Forced Expiratory Volume in First Second (FEV1)and FEV1/FVC% with Plasma Progesterone Level during Different Phases of Normal Menstrual Cycle

Sultana Rokeya Mannan, Noorzahan Begum, Shelina Begum, Sultana Ferdousi, Taskina Ali
2008 Journal of Bangladesh Society of Physiologists  
The present study was carried out to observe the correlation of some lung function parameters with the endogenous plasma progesterone level during different phases of menstrual cycle. The study was conducted on 30 healthy young female volunteers with age range of 20-25 years in the department of Physiology of BSMMU, Dhaka, during July 2005-June 2006. All the subjects were studied in 3 phases of menstrual cycle for 2 consecutive cycles. FVC, FEV 1 , FEV 1 /FVC% for assessing lung function and
more » ... ung function and plasma Progesterone level during each phase of menstrual cycle were measured by a portable spirometer and by ELIZA method in auto analyzer respectively. Comparison of the values between different phases were done by paired 't' test considering menstrual phase data as baseline due to negligible amount of progesterone detected in this phase. Correlation of FVC , FEV 1 and FEV 1 /FVC%with Progesterone level in each 3 phases were analyzed by Pearson's correlationcoefficient test. Plasma progesterone level was much higher during luteal phase compared to those of follicular phases of both cycles (24.54ng/ml vs1.41 ng/ml; 26.56 ng/ml vs. 1.48 ng/ml). Both FVC and FEV 1 were significantly higher (p<0.001) during luteal phase than those of follicular phases in both the cycles. FVC, FEV 1 and FEV 1 /FVC%were positively correlated with plasma progesterone level but these relationships had failed to show any statistical significance. Similar to others, this study also observed increased ventilation and high endogenous progesterone level during luteal phase. Therefore increased ventilation might be related to high progesterone level during luteal phase owing to increased inspiratory muscle endurance and bronchial relaxation effect.
doi:10.3329/jbsp.v2i0.976 fatcat:o33vdy6y3zd53lylkldt3lc5oy