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Journal of Virology
The sequenced gammaherpesviruses each contain a single viralbcl-2 homolog (v-bcl-2) which may encode a protein that functions in preventing the apoptotic death of virus-infected cells. Epstein-Barr virus (EBV), a gammaherpesvirus associated with several lymphoid and epithelial malignancies, encodes the v-Bcl-2 homolog BHRF1. In this report the previously uncharacterized BALF1 open reading frame in EBV is identified as having significant sequence similarity to other v-bcl-2 homologs and cellulardoi:10.1128/jvi.73.6.5181-5185.1999 fatcat:qlnu6lbidnbjdbcephddiy7rea