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Staphylococcal enterotoxin B and α-toxin induce the apoptosis of ECV304 cells via similar mechanisms
2013
Molecular Medicine Reports
Staphylococcal enterotoxin B (SEB) and α-toxin produced by Staphylococcus aureus (S. aureus) are important in the pathogenesis of diseases. In the present study, we investigated the effects of SEB and α-toxin on ECV304 cells. It was identified that both SEB and α-toxin were capable of inducing the apoptosis of ECV304 cells in a dose-and time-dependent manner. In addition, SEB and α-toxin were able to induce the expression of TNF-α and the activation of caspase-3 and -8 in the ECV304 cells. The
doi:10.3892/mmr.2013.1550
pmid:23799615
fatcat:22k2j3evxbdi3nmnvlyt4esbbe