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Modeling of epigenome dynamics identifies transcription factors that mediate Polycomb targeting
2013
Although changes in chromatin are integral to transcriptional reprogramming during cellular differentiation, it is currently unclear how chromatin modifications are targeted to specific loci. To systematically identify transcription factors (TFs) that can direct chromatin changes during cell fate decisions, we model the relationship between genome-wide dynamics of chromatin marks and the local occurrence of computationally predicted TF binding sites. By applying this computational approach to a
doi:10.5167/uzh-78865
fatcat:ntrzrrhruve2xiamwikc2utlfq