Differential Effects ofNaja naja atraVenom on Immune Activity

Jian-Qun Kou, Rong Han, Yin-Li Xu, Xiao-Lan Ding, Shu-Zhi Wang, Cao-Xin Chen, Hong-Zhang Ji, Zhi-Hui Ding, Zheng-Hong Qin
2014 Evidence-Based Complementary and Alternative Medicine  
Previous studies reported thatNaja naja atravenom (NNAV) inhibited inflammation and adjuvant arthritis. Here we investigated the role of NNAV in regulation of immune responses in mice. Oral administration of NNAV to normal mice showed significant increase in natural killer cell activity, B lymphocyte proliferation stimulated by lipopolysaccharides, and antibody production in response to sheep red blood cells. Meanwhile, NNAV markedly decreased T lymphocyte proliferation stimulated by
more » ... n A, arrested the cell cycle at G0/G1phase, and suppressed CD4 and CD8 T cell divisions. Furthermore, NNAV inhibited the dinitrofluorobenzene-induced delayed-type hypersensitivity reaction. This modulation of immune responses may be partly attributed to the selective increase in Th1 and Th2 cytokines (IFN-γ, IL-4) secretion and inhibition of Th17 cytokine (IL-17) production. In dexamethasone-induced immunosuppressed mice, NNAV restored the concentration of serum IgG and IgM, while decreasing the percentage of CD4 and CD8 T-cell subsets. These results indicate that NNAV enhances the innate and humoral immune responses while inhibiting CD4 Th17 and CD8 T cell actions, suggesting that NNAV could be a potential therapeutic agent for autoimmune diseases.
doi:10.1155/2014/287631 pmid:25024726 pmcid:PMC4082923 fatcat:66aqj4d6yncq7jm6evqyfzdjwq