Amyloid angiopathy may contribute to white‐matter hyperintensities in Alzheimer's disease

Ying Xia, Amir Fazlollahi, Paul A. Yates, Nawaf Yassi, Patricia M. Desmond, Olivier Salvado, Victor L.L. Villemagne, Christopher C. Rowe, Jurgen Fripp, Colin L. Masters, Parnesh Raniga
2020 Alzheimer's & Dementia  
Cerebral amyloid angiopathy (CAA) is characterised by the accumulation of amyloid-b (Aβ) in cerebral vessels and is often coexistent with Alzheimer's disease (AD). However, the overlap between CAA and AD and the contribution of CAA pathology to cerebrovascular lesions are not well understood. We hypothesize that in subjects with high Aβ load, the presence of imaging markers of CAA would be associated with greater white matter hyperintensities (WMH) burden. Method: Data used in the preparation
more » ... this article was obtained from the Australian Imaging Biomarkers and Lifestyle flagship study of ageing (AIBL). See www.aibl.csiro. au. We analysed MRI (SWI and FLAIR) and 11C-PiB-PET data from 98 cognitively nor-
doi:10.1002/alz.038899 fatcat:syzs4h77pzehtljwyudgjmncaa