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High-Resolution Structural Analysis of Chromatin at Specific Loci:Saccharomyces cerevisiaeSilent Mating-Type LocusHMRa
1999
Molecular and Cellular Biology
Genetic and biochemical evidence implicates chromatin structure in the silencing of the two quiescent mating-type loci near the telomeres of chromosome III in yeast. With high-resolution micrococcal nuclease mapping, we show that theHMRa locus has 12 precisely positioned nucleosomes spanning the distance between the E and I silencer elements. The nucleosomes are arranged in pairs with very short linkers; the pairs are separated from one another by longer linkers of ∼20 bp. Both the basic
doi:10.1128/mcb.19.12.7944
pmid:10567520
pmcid:PMC84879
fatcat:uemdeigvlrezji2hotabzzesvi