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Designing and Construction of a Multiepitope-Based DNA Vaccine to Induce Protective Immunity against Hepatitis C Virus
Arak Medical University Journal (AMUJ)
Hypervariability of hepatitis C virus (HCV) proteins is an important obstacle to design an efficient vaccine for the infection. To construct a protective vaccine against HCV, a DNA vaccine containing conserved epitopes of the virus was designed. To enhance the induced immune responses, adjuvant activity of N-terminal domain of gp96 (NT(gp96)) was used. Materials and Methods: A multi-epitope (PT) DNA vaccine encoding four HCV immunodominant cytotoxic T lymphocyte epitopes (HLA-A2 and H2-D d)fatcat:tn7b7webubcz3hrrpfkm3ounlm