The systemic and local content of inflammatory cytokines and chemokines play substantial roles in pathophysiology of arthritis. This study was purposed to verify the roles of synovial TNF-α, IL-6 and fractalkine (Fkn) in edema changes during different stages of Complete Freund's Adjuvant (CFA)induced knee arthritis in rats. Methods: 168 male Wistar rats were divided in 7 groups and each group was divided to 4 subgroups. Each subgroup contains 6 male rats. Arthritis was evoked into the right

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... joint. Changes in knee edema were evaluated by caliper and synovial TNF-α and IL-6 levels were assayed by rat standard ELISA kit in homogenized synovial tissues on days 0, 7, 14 and 21 of study. Synovial Fkn content was assessed during different stages of study using western blot. For analysis of within-groups differences, ANOVA followed by post hoc Tukeys was used. Unpaired student t-test was used for analysis of differences between groups.