Effect of Aminophylline on Regional Perfusion Distribution in the Lungs

TOYOHARU ISAWA, TAKEO TESHIMA, TOMIO HIRANO, KOICHIRO SHIRAISHI, TAKASHI MATSUDA, KIYOSHI KONNO
1979 Tohoku journal of experimental medicine  
Using ten normal dogs , the right upper lobe of the lung was isolated in vivo by a balloon catheter and was artificially ventilated with nitrogen, air, 60% oxygen in nitrogen , and 60% oxygen and 20% carbon dioxide in nitrogen, while the rest of the lungs maintained a spontaneous breathing of ambient air. Aminophylline did not show a vasodilating action under severe alveolar hypoxia (PAO ,: ca. 40 mmHg); on the contrary, it seemed to potentiate hypoxic pulmonary vasoconstriction. When the
more » ... ion. When the regional alveolar oxygen tension became less hypoxic (PAO ,: ca.. 70 mmHg) or higher than that in the rest of the lungs which spontaneously breathed ambient air, aminophylline showed a definite vasodilating action. Aminophylline also showed a vasodilating action in alveolar hypercapnia in the presence of alveolar hyperoxia. aminophylline; vasodilator; severe alveolar hypoxia; alveolar hyperoxia; bronchodilation Received for publication, August 9, 1978.
doi:10.1620/tjem.128.345 fatcat:cfs4zqj4mbdvxoyszwmtn7lhya