Allergy is an adverse immunologic response of increasing prevalence and severity in which immunoglobulin E plays a pivotal role. Total IgE (tIgE) levels show wide variations depending on various factors, such as age, sex, ethnicity, and geographic area. This study set out to quantitatively determine the serum tIgE levels in Bangladeshi population who were clinically suspected cases of allergic diseases and to find out the association of tIgE level with their age and gender. This cross-sectional

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... descriptive exploratory study was conducted at Biomed Diagnostics Laboratory, Panthapath, Dhaka, from March 2021-September 2021. A total of 402 blood samples were collected from clinically suspected cases of allergic diseases. Quantitative detection of tIgE in serum was done by Immunoblot assay manufactured by Proteome Tech Inc. (PROTIA TM Allergy-Q64S panel). Among 402 subjects, a wide variation of tIgE levels ranging from 5 to 2000 IU/ml was found but majority of the study population (30.35%) showed tIgE levels within the range of 201 -350 IU/ml. The study population aging 1 -10 years showed highest frequency (23.63%) in tIgE concentrations and the mean tIgE level exhibited a declining tendency with an increase in age. Depending on gender there was no difference in tIgE levels. Determination of tIgE level is imperative for screening allergic diseases. The present study enlightened the distribution of tIgE levels and suggested that among Bangladeshi subjects irrespective of gender there is an inverse relationship between tIgE level and age.