A Review of Neuroimaging Findings in Repetitive Brain Trauma

Inga K. Koerte, Alexander P. Lin, Anna Willems, Marc Muehlmann, Jakob Hufschmidt, Michael J. Coleman, Isobel Green, Huijun Liao, David F. Tate, Elisabeth A. Wilde, Ofer Pasternak, Sylvain Bouix (+4 others)
2015 Brain Pathology  
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease confirmed at postmortem. Those at highest risk are professional athletes who participate in contact sports and military personnel who are exposed to repetitive blast events. All neuropathologically-confirmed CTE cases, to date, have had a history of repetitive head impacts. This suggests that repetitive head impacts may be necessary for the initiation of the pathogenetic cascade that, in some cases, leads to CTE. Importantly,
more » ... while all CTE appears to result from repetitive brain trauma, not all repetitive brain trauma results in CTE. Magnetic resonance imaging has great potential for understanding better the underlying mechanisms of repetitive brain trauma. In this review we provide an overview of advanced imaging techniques currently used to investigate brain anomalies. We also provide an overview of neuroimaging findings in those exposed to repetitive head impacts in the acute/subacute and chronic phase of injury and in more neurodegenerative phases of injury, as well as in military personnel exposed to repetitive head impacts. Finally, we discuss future directions
doi:10.1111/bpa.12249 pmid:25904047 pmcid:PMC5699448 fatcat:54sffdgi2bfxhpfx2uj66yabxq