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Previous H 2 15 O PET activation studies on patients with showed impaired activation of the contralateral primary motor cortex, but enhanced activation of frontal association idiopathic torsion dystonia (ITD) have shown overactive striatum and frontal accessory areas and underactivity of cortex. Botulinum-toxin treatment improved writing and increased activation in parietal cortex and caudal SMA. the primary motor cortex and caudal supplementary motor area (SMA) during volitional movement. Wedoi:10.1093/brain/120.4.571 pmid:9153120 fatcat:noxb2zklwjeizbhtl2cag2szjy