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Evaluation of a Systematic Substitution of Zidovudine for Stavudine-Based HAART in a Program Setting in Rural Cambodia
Journal of Acquired Immune Deficiency Syndromes
Objective: To evaluate a treatment strategy of substituting zidovudine (ZDV) for stavudine (d4T)-based highly active antiretroviral therapy (HAART), aimed at preventing d4T-associated toxicity, in a programmatic setting in rural Cambodia. Methods: Survival probability, CD4 gain, anemia incidence, and factors associated with severe anemia were analyzed in a cohort of adult patients switched from d4T-to ZDV-containing regimens from Results: Among 527 patients systematically switched to ZDV afterdoi:10.1097/qai.0b013e31817bec19 pmid:18667931 fatcat:w4dp73rfmjdntlhmmvvpumcriy