Loss of Kif18A Results in Spindle Assembly Checkpoint Activation at Microtubule-Attached Kinetochores

Louise M.E. Janssen, Tessa V. Averink, Vincent A. Blomen, Thijn R. Brummelkamp, René H. Medema, Jonne A. Raaijmakers
2018 Current Biology  
Graphical Abstract Highlights d Loss of Kif18A results in decreased tension across KTs, SAC activation, and cell death d SAC deficiency rescues the lethality caused by Kif18A loss d DMad2DKif18A cells are viable and do not display increased missegregations d SAC-active kinetochores of Kif18A-depleted cells display robust k-Mt attachments
doi:10.1016/j.cub.2018.06.026 pmid:30122526 fatcat:yj2xido4ybdt5adwyqaoeby6ly