The purpose of this study is to estimate the effects of the drip infusion therapy with argatroban and its sustenance. 14 patients who had failed conservative treatment were administered argatroban (20mg/day) for 2 weeks. 12 patients showed someimprovements in their symptoms following this treatment. No patients worsened. The mean JOA score significantly improved from 12.9 points to 19.4 points. Most subjective symptoms showed significant improvement, but not objective symptoms. 5 patients had

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... ntinuous improvements for more than a mean of 17.8 months, but 4 patientsshowed recurrence after a mean followup of 3.7 months. These results suggest that drip infusion therapy with argatroban is recommended for lumbar spinal canal stenosis.