6-shogaol suppresses oxidative damage in L6 muscle cells

Jinyoung Hur, Yeonmi Lee, Chang Jun Lee, Ho-Young Park, Sang Yoon Choi
2020 Applied Biological Chemistry  
AbstractGinger (Zingiber Officinale Roscoe) has been known reduce muscle pain after exercise, and 6-shogaol {(E)-1-(4-Hydroxy-3-methoxyphenyl)dec-4-en-3-one)} is the major essential oil contained in ginger. In this study, the protective effect of 6-shogaol on L6 muscle cells against oxidative damage was measured. 6-shagol inhibited the damage of L6 cell induced by H2O2, and allowed the increase in mRNA and protein expression levels of intracellular HO-1 and NRF2. 6-shogaol also reduced the
more » ... ction of intracellular ROS. These results suggested that 6-shagol effectively inhibits oxidative damage of skeletal muscle cell.
doi:10.1186/s13765-020-00544-8 fatcat:hpwrfxrutfft7ey6j47jkaw4my