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In schizophrenia and bipolar disorder, tight junction deficits in brain microvascular endothelial cells (BMECs) lead to blood brain barrier (BBB) dysfunction. Using an in vitro model of human BBB function, we show that BMECs derived from human induced pluripotent stem cells of schizophrenia patients show reduced BBB integrity and increased small molecule permeability when compared to healthy control BMECs. Stratification based on BBB function in schizophrenia and bipolar disorder patientsdoi:10.21203/rs.3.rs-1162029/v1 fatcat:ykyp2u6j7ffwxf46wyagobzxem