Effect of indomethacin on egg transport and pregnancy in the rabbit

A. A. El-Banna, B. Sacher, E. Schilling
1976 Reproduction  
Treatment of rabbits with indomethacin (10 mg/kg/day) 48 hr before mating, and with 20 mg/kg at 12 hr followed by 8 mg/kg at 48, 72 or 96 hr after mating did not affect the rate of egg transport through the oviduct. Indomethacin treatment at the time of implantation interfered with pregnancy and caused degeneration and resorption of embryos. These results suggest that inhibition of prostaglandin synthesis does not directly affect egg transport, but that prostaglandin appears to be required for the retention of implanted embryos.
doi:10.1530/jrf.0.0460375 pmid:1255565 fatcat:3tlzkbv7bnginkuxfirzks3444