There are contradictory opinions about the effect of coffee on serum markers of atherogenesis in the literature. This study aimed to assess the effect of decaffeinated coffee consumption on serum lipid levels, atherogenic index of plasma (AIP), and markers of carbohydrate (CHO) metabolism, in diet-induced dyslipidemia in rats. Twenty-five Wistar albino rats were divided into 5 groups (n=5per group). Animals in group 1 served as a normal control group (NCTRL) and were given a normal diet and

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... r only. Animals in group 2 received a hyperlipidemic diet. Animals in groups 3, 4, and 5 in addition to the hyperlipidemic diet were treated with low, medium, and high doses of decaffeinated coffee respectively for 28 days. At the end of the coffee treatment, and 8h after feeding, all animals were sacrificed and blood obtained was analyzed for the biochemical indices of atherogenesis and CHO metabolism using standard methods. There were significant (P<0.05) increases in serum levels of total cholesterol (TC), triglyceride cholesterol (TG-C), lowdensity lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), AIP, and markers of CHO metabolism (FBG, insulin, and Homeostatic Model Assessment of Insulin Resistance (HOMA-IR)), as well as a decrease in highdensity lipoprotein cholesterol (HDL-C) in the hyperlipidemic alone group. Treatment with different doses of decaffeinated coffee caused a reversal of these indices to near levels in the control group in a dose-dependent manner, especially in the medium-dose group. Moderate consumption of decaffeinated coffee can ameliorate diet-induced dyslipidemia and improved markers of CHO metabolism.