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Determinants of telomere length across human tissues [article]

Kathryn Demanelis, Farzana Jasmine, Lin S Chen, Meytal Chernoff, Lin Tong, Justin Shinkle, Mekala Sabarinathan, Hannah Lin, Eduardo Ramirez, Meritxell Oliva, Sarah Kim-Hellmuth, Barbara E Stranger (+7 others)
2019 bioRxiv   pre-print

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Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in non-blood, disease-relevant tissue types. Here we characterize variability in TL measurements for 6,391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) Project. We describe differences across tissue types, positive correlation
more » ... g tissue types, and associations with age and ancestry. We show that genetic variation impacts TL in multiple tissue types, and that TL can mediate the effect of age on gene expression. Our results provide the foundational knowledge regarding TL in healthy tissues that is needed to interpret epidemiological studies of TL and human health.
doi:10.1101/793406 fatcat:wamswi4ufvblvgtbstg2icho2a
Citation

Kathryn Demanelis, Farzana Jasmine, Lin S Chen, Meytal Chernoff, Lin Tong, Justin Shinkle, Mekala Sabarinathan, Hannah Lin, Eduardo Ramirez, Meritxell Oliva, Sarah Kim-Hellmuth, Barbara E Stranger, Kristin G Ardlie, François Aguet, Habibul Ahsan, Jennifer Doherty, Muhammad G Kibriya, Brandon L Pierce, GTEx Consortium. "Determinants of telomere length across human tissues." bioRxiv (2019)