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CYP2E1 in the Human Retinal Pigment Epithelium: Expression, Activity, and Induction by Ethanol
2015
Investigative Ophthalmology and Visual Science
PURPOSE. Cytochrome p450 2E1 (CYP2E1) is a detoxifying enzyme with particular affinity for ethanol (EtOH) expressed in several tissues. Although CYP2E1 has been identified in human RPE, nothing is known about its metabolic activity. Expression of CYP2E1 and activity after EtOH exposure have been studied in human RPE and ARPE-19 cells. METHODS. Ethanol-induced CYP2E1 mRNA expression was analyzed by RT-PCR and quantitative PCR (qPCR) from human donor RPE as well as from ARPE-19 cells. Expression
doi:10.1167/iovs.14-16291
pmid:26567798
fatcat:6muxy7vofredxmug4j3gbktleq