Comparison of Gamma-glutamyl Transferase and Troponin-I Levels in Patients Presenting with Acute Coronary Syndrome
Indian Journal of Medical Biochemistry
Atherosclerosis is the predominant cause of acute coronary syndrome, and is usually associated with rupture of an atherosclerotic plaque resulting in the formation of partial or complete thrombosis of the coronary artery. The main objective of the study is to compare the levels of biochemical marker of atherosclerosis-gamma-glutamyl transferase (GGT) and sensitive marker of myocardial necrosis-cardiac Troponin-I (cTnI) in patients presenting with acute coronary syndrome (ACS). Materials and
... . Materials and methods: The design was a prospective casecontrol study where a total of 161 patients, 110 ACS patients and 51 control subjects with the age group of 30 to 80 years were enrolled for the study. GGT was estimated by kinetic colour test using Beckman Coulter AU2700 analyser. Troponin-I was estimated by chemiluminescent micro particle immunoassay using Abbott ARCHITECT system. Results: The mean GGT levels of ST-segment elevation myocardial infarction (STEMI), non-ST-segment elevation myocardial infarction (NSTEMI) and unstable angina (UA) subgroups were 91.58, 84.12 and 30.46 U/L respectively, which showed a statistically significant difference (p < 0.001) when compared with control subjects. The mean Troponin-I levels of STEMI, NSTEMI and UA subgroups were 14.31, 4.68 and 0.02 ng/mL respectively, which showed a statistically significant difference (p < 0.001) when compared with control subjects. Correlation between GGT and Troponin-I done using Spearman's Rho coefficient correlation test showed a positive correlation between GGT and Troponin-I in ACS patients. Conclusion: Gamma-glutamyl transferase (GGT) level elevates as an indicator of increased oxidative stress in patients with coronary artery disease who are not alcoholic and have no liver disease. The strong correlation between GGT and Troponin-I complement the usefulness of gamma-glutamyl transferase for predicting troponin positivity in patients presenting with acute coronary syndrome.