A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2018; you can also visit the original URL.
The file type is application/pdf
.
The Anticonvulsant Tiagabine Inhibits Cocaine's Rewarding Effects, but has No Effect on Reinstatement of Cocaine-Seeking Behavior in Rats
2013
Biochemistry & Pharmacology Open Access
GABA is an important neurotransmitter involved in drug abuse and addiction. Accordingly, drugs that elevate brain GABA levels are thought to be promising for the treatment of addiction. In the present study, we report that tiagabine, a selective type 1 GABA transporter inhibitor that has been approved by the U.S. FDA as an anticonvulsant drug, may have therapeutic potential in reducing cocaine use. In vivo brain microdialysis studies demonstrated that systemic administration of tiagabine (3,
doi:10.4172/2167-0501.s1-005
fatcat:77nkpwsbrbbotjketcsx6stwne