Objective: The aim of this study was to investigate the effect of Resistance Training (RT) with Genistein on Interleukin-6 (IL-6) and C-reactive protein (CRP) in diabetic rats. Materials and Methods: 64 induced diabetic rats into 8 groups were investigated with experimental study: first week control, last week control, RT, 15 mg/kg Genistein consumption, resistance exercise with 15 mg/kg Genistein consumption, 30 mg/kg Genistein consumption, resistance exercise with 30 mg/kg Genistein

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... n and placebo (dimethyl sulfoxide). Rats in groups 3, 5 and 7 performed 8 weeks of RT with 30 to 100% of body weight in 3 weekly sessions, and groups 4, 5, 6, and 7 received Genistein peritoneally with the mentioned doses. Also, to investigate the effects of diabetes induction on the study variables, 16 healthy rats were selected and divided into two groups: healthy first week control and healthy last week control. The data were analyzed using independent sample T-tests, two-way and one-way ANOVA with Bonferroni's post-hoc test in SPSS software (P-value≤ 0.05). Results: RT had a significant effect on CRP reduction in induced diabetic rats (P-value≤ 0.05). Genistein consumption decreased IL- 6 and CRP in diabetic rats (P-value≤ 0.05). Moreover, the interaction between RT and Genistein consumption had statistically significant effects on the reduction of IL-6 and CRP in diabetic rats (P-value≤ 0.05); 15 mg/kg Genistein consumption had a greater effect on the reduction of CRP than 30 mg/kg Genistein consumption in induced diabetic rats (P-value≤ 0.05). Conclusion: RT alone could not significantly reduce the levels of IL-6 in induced diabetic rats; however, it seems that Genistein consumption with RT have interactive effects on reducing inflammatory factors in induced diabetic rats.