Profile of Liver Dysfunction in Plasmodium Vivax Malaria

Ashwini Nigam, Ashish Gautam, Bechan Kumar Gautam, Sanjay Singh
2017 International Journal of Contemporary Medical Research   unpublished
Malaria due to P. vivax infection increased now days. Vivax malaria causes organ failure by inflammation and sequestration. P. vivax mono-infection could also result in multiple organ dysfunction and severe life-threatening disease as seen in P. falciparum infection. Study aimed to describe the various clinical manifestations and biochemical parameter for liver dysfunction in association with P. vivax malaria. Material and methods: This prospective observational study was carried out at
more » ... ried out at Sarojini Naidu Medical College, Agra. It included all the cases presented with fever with evidence of jaundice. Diagnosis of malaria was confirmed by both thick and thin blood film stained with Leishman's stain for malarial parasite and M. P. Elisa. Detailed history, clinical examination, biochemical parameter for liver function was done in all patients. Results: 200 P. vivax positive cases were included in the study (96 males and 104 females) out of which 54 (27%) patients have serum bilirubin >3mg/dl (48 patients, serum bilirubin 3-10mg% and 6 patients with >10 mg%). Out of 54 patients having serum bilirubin >3mg/dl, 33 patients had more increase in indirect bilirubin and 21 patients had more increase in direct bilirubin. SGOT 40-120IU/L was present in 99 cases and >120IU/L was present in 42 patients. SGPT 40-120IU/L was present in 99 cases and >120IU/L was present in 12 cases. Conclusion: Severe vivax malaria now very common with increasing liver dysfunctions which is more common in young people evident by the level of serum bilirubin and liver enzymes.