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ENHANCEMENT OF SOLUBILITY AND DISSOLUTION RATE OF CURCUMIN BY SOLID DISPERSION TECHNIQUE
International Research Journal of Pharmacy
Curcumin, a naturally occurring highly lipophilic molecule has wide range of pharmacological activities. However, its limitedaqueous solubility and degradation at alkaline pH restricts its bioavailability. Solid dispersions (SD) of curcumin-polyethylene glycol (PEG 4000, 6000) in the ratio of 1:3, 1:5, and 1:10 wereprepared in an attempt to increase the solubility and dissolution by fusion method. Physical characterization by IR, DSC studies, in comparison with corresponding physical mixturesdoi:10.7897/2230-8407.04548 fatcat:uhsb33yshrdnlj7hs3bijdjqom