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Hypopituitarsim Is Associated with Triglyceride Enrichment of Very Low-Density Lipoprotein
Journal of Clinical Endocrinology and Metabolism
The dyslipidemia associated with hypopituitarism may contribute to increased vascular mortality. The atherogenic potential of lipoproteins is determined not only by concentration but also by their composition. We therefore studied very low-density lipoprotein composition and apolipoprotein B kinetics in 16 hypopituitary subjects and 16 controls. Hypopituitarism was associated with reduced high-density lipoprotein cholesterol (0.98[0.82-1.18] vs. 1.35[1.15-1.41] mmol/liter, P < 0.001) and increased triglyceride concentrations (1.doi:10.1210/jc.86.8.3900 pmid:11502830 fatcat:clbaoyseibgbba6uv5nw4dy2t4