Objective: The aim of the study was the preparation and characterization of the transdermal films of jackfruit leaves extract. Methods: A transdermal film loaded jackfruit leaves extract was formulated with chitosan as polymer and used variation concentration of plasticizer are combination from sorbitol and glycerol. The formulation was evaluated organoleptic, stability, folding resistance, uniformity of weight and thickness, water vapor transmission rate, retention capacity, FTIR spectrum, and

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... drug release test. Results: The results of the organoleptic test showed that the film was flexible, greenish-yellow in color, and had stable physical stability in the preparation. The increase in the concentration of plasticizer also had a significant effect (p<0.05) on the tensile strength test, uniformity of weight and film thickness, water vapor transmission rate, and retention capacity. The results of the FTIR test showed that there was a cross-linking interaction marked by the presence of a new peak at the wavenumber of 1556.31 cm-1. The best penetration test results are found in formula 2 with % penetration of 31.95% and J of 18.08 g cm-2 h-1. Conclusion: All three formulas of transdermal films of jackfruit leaves extract have met the requirements and F2 showed best in vitro release than F1 and F3.