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Prevention of Angiotensin II-Mediated Renal Oxidative Stress, Inflammation, and Fibrosis by Angiotensin-Converting Enzyme 2
Angiotensin-converting enzyme 2 (ACE2) is a monocarboxypeptidase capable of metabolizing angiotensin (Ang) II into Ang 1 to 7. We hypothesized that ACE2 is a negative regulator of Ang II signaling and its adverse effects on the kidneys. Ang II infusion (1.5 mg/kg Ϫ1 /d Ϫ1 ) for 4 days resulted in higher renal Ang II levels and increased nicotinamide adenine dinucleotide phosphate oxidase activity in ACE2 knockout (Ace2 Ϫ/y ) mice compared to wild-type mice. Expression of proinflammatorydoi:10.1161/hypertensionaha.110.164244 pmid:21189404 fatcat:qlpotmhaxzc6pnwgowqg33cnuu