Adipose tissue's phenotypic alteration due to exercise training is a new theory. However, the cellular-molecular mechanisms for these phenotypic alterations are not yet clearly understood. The aim of this study was to investigate the effects of six weeks resistance training on Meteorin-like hormone level and insulin resistance index in overweight adolescent boys. Materials and Methods: Twenty overweight adolescent boys (average age 18.5±1 years old, average weight 81.1±4.5 kg, and BMI 27.7±0.7

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... g/m 2) participated in this study. The subjects were randomly assigned into two groups: control (N=10) and resistance training (N=10). Subjects in training group performed six-week resistance training program 3 days/week. Anthropometrics parameters and fasting serum of Meteorin-like hormone levels, insulin and glucose were measured at the baseline and at the end of study. Results: The level of Meteorin-like hormone was significantly decreased in control group (p=0.008), but that of Meteorin-like hormone in resistance training was increased insignificantly (p=0.311). The variations of Meteorin-like hormone levels between two groups were significant (p=0.004). The changes of insulin resistance were increased in both groups which were statistically significant (p=0.032) and insignificant (p=0.632) for control and training groups respectively. We found a negative and insignificant correlation between changes in Meteorin-like hormone levels and changes in insulin resistance index (p=0.273). Conclusion: The results showed that six weeks' resistance training has no effect on increasing Meteorin-like hormone serum level and improving insulin resistance index and body composition in overweight adolescent boys.