Composite type A thymoma and diffuse large B-cell lymphoma

Hsin-I Chen, Chee-Yin Chai, Shih-Feng Cho, Jui-Ying Lee, Wan-Tzu Chen, Chun-Chieh Wu
2015 Tzu-Chi Medical Journal  
The concurrent occurrence of thymoma and diffuse large B-cell lymphoma in the thymus has not been previously reported. We describe a 74-year-old man who presented with general weakness, neck lymphadenopathy, night sweats, and body weight loss. A right anterior mediastinal mass was found on computed tomography of the chest. The immunohistochemical stains AE1/AE3, CD20, CD3, and MUM-1 confirmed the different components of the mediastinal tumor. A heavy-chain gene clonality assay and light-chain
more » ... y and light-chain gene clonality assay confirmed the B-cell clonality of the mediastinal tumor and neck lymph node. The patient had received a complete course of chemotherapy, and the result of positron emission tomographyecomputed tomography showed complete remission. The pathologic report of this mass revealed composite type A thymoma and diffuse large B-cell lymphoma. If concurrent or composite thymoma and lymphoma are suspected, a thorough examination of the thymoma with a combination of ancillary studies is recommended to rule out the possibility of concurrent lymphoma.
doi:10.1016/j.tcmj.2014.05.009 fatcat:4dxfayqe2vg77oyyi2p5l5obue