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Randomized trials assessing the effect of systemic corticosteroids on chronic obstructive pulmonary disease (COPD) exacerbations excluded patients who were mechanically ventilated or admitted to the intensive care unit (ICU). Critically ill patients constitute a population of persons who are prone to develop complications that are potentially associated with the use of corticosteroids (eg, infections, hyperglycemia, ICUacquired paresis) that could prolong the duration of mechanical ventilationdoi:10.1001/archinternmed.2011.530 pmid:22123804 fatcat:fpefssenk5dmbmmzfykvoywt2q