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The macromolecular diversity and concentrations in the fluid phase of cytoplasm constitute conditions necessary and sufficient for aqueous phase separation. Consequences of phase separation in cytoplasm, including its 'compartmentation', are inferred from analogies with the physicochemical properties of aqueous two-phase systems and with the partitioning behavior of biomaterials in them.doi:10.1016/0014-5793(95)00159-7 pmid:7698310 fatcat:xj5ps5mx4vcl7jdtydwgvbrx2e