Profound Thrombocytopenia after Treatment with Tirofiban; On-Pump Surgery for Acute Aortic Dissection and Coronary Bypass Surgery

Beckers Stefan, Remory Isabel
2013 Cardiovascular Pharmacology Open Access  
We describe the case of a 69-year-old man who developed glycoprotein IIb/IIIa receptor (GPIIb/IIIa) antagonist associated thrombocytopenia and the successful management during urgent aortic dissection and coronary artery bypass grafting. A flow cytometric assay was developed to confirm the diagnosis of GPIIb/IIIa-antagonist induced thrombocytopenia. This case was further complicated by the concomitant presence of heparine/PF4 platelet antibodies, but was proven not to be the causal factor of the thrombocytopenia.
doi:10.4172/2329-6607.1000105 fatcat:2diox6yqyzevtmqghke5svoxhi