Sensitization Potentials and Immunologic Specificities of Neomycins

Choong W Chung, Theophilus R Carson
1975 Journal of Investigative Dermatology  
The use of sensitization indices for expressing allergenic skin reactions in guinea pigs is described. The method is convenient for comparing allergens and cross-reacting substances and permits the use of both irritating and nonirritating challenge concentrations of allergens. It also permits determination of both optimal reading time and challenge concentrations for each experiment. By this technique commercial neomycin complex, neamine (neomycin Al, neomycin B, neomycin C. and streptomycin
more » ... and streptomycin were found to be allergenic in guinea pigs via intradermal ( id) and foot-pad (fp) immunizations. The immunizing emulsion consisted of an allergen and an adjuvant containing Mycobacterium butyricum (MBl or Mycobacterium tuberculosis H37Ra (Ral. The adjuvant MB was as effective as Ra by the id route, but
doi:10.1111/1523-1747.ep12533314 pmid:804015 fatcat:p4vovcuf3vdwnpq2rowwj3exqu