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The effect of leflunomide on the transplanted endometriosis lesions in SD rats

J.J. Yang, Y. Gao, Y.H. Wang, C.H. Wang, L.D. Wang, B.B. Tao, H.F. Guo, S.G. Ding, A.H. Wu, G.R. Zhai, X.M. Feng
2017 Clinical and experimental obstetrics & gynecology  

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Objective: To investigate the effects of the leflunomide (LEF) on the size of the transplanted endometriosis (EMS) lesions and transforming growth factor (TGF) -β1gray level in SD rats. Materials and Methods: EMS was surgically induced in rats by autologous transplantation and the focal volume was also measured. The rats were divided into three groups: group A: normal SD rats, group B: rats irrigated by one ml•kg -1 •d -1 saline for three weeks, and group C: rats irrigated by 35 mg•kg -1 •d -1
more » ... EF for three weeks. The rats were then sacrificed and measured their focal volume and TGF-β1 gray value with immunohistochemical method. Results: The sizes of the focal volume in group C were significantly reduced compared to the rats before feeding, and the volume in group C was smaller than group B after feeding and so was the TGF-β1. Conclusion: LEF could be a new therapeutic drug for EMS.
doi:10.12891/ceog3148.2017 fatcat:pnmetjiczjcxvih46vhtpzwfta
Citation

J.J. Yang, Y. Gao, Y.H. Wang, C.H. Wang, L.D. Wang, B.B. Tao, H.F. Guo, S.G. Ding, A.H. Wu, G.R. Zhai, X.M. Feng. "The effect of leflunomide on the transplanted endometriosis lesions in SD rats." Clinical and experimental obstetrics & gynecology 44.1 (2017) 129-132